Hpv head neck cancer prognosis. Human papillomavirus 52 positive squamous cell carcinoma of the conjunctiva


Zodia cancerului pareri These tumours of oral cavity, oropha­rynx, larynx, parazit lambliaza and sinonasal region are linked by common characteristics, including a male predominant appearance in the 5th-6th decade of life, an important etiological link hpv oropharyngeal cancer survival tobacco, alcohol use or betel nut chewing, and a histopathological resemblance 1.

Data regarding the epidemiology revealed that in Romania the oropharyngeal cancer represents 2. In France, during the last 30 years, the mortality in oral and oropharyngeal cancer increased hpv oropharyngeal cancer survival three times 1.

As in cervical cancers, the oropharyngeal infection with HPV is a sexually transmitted disease which involves some particularities of sexual behaviour: a large number of vaginal sex partners, oral and anal sex.

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The recent increasing of OPSCC incidence may reflect the social changes regarding sexual behaviour in the modern world 6. The anatomical sites preferred by HPV in oropharynx are the tonsils and the tongue, because of the unique presence of transitional mucosa in oropharynx and particular in tonsillar tissue, which presents important histological similarities with the cervical mucosa.

Tonsillar epithelium invagination may favour virus capture and promote its access to basal cells the only dividing cells in the epithelium. The tonsillar tissue could be a reservoir for HPV in the upper aero hpv oropharyngeal cancer survival tract.

Case Report

We had two premises for our study on tonsillar cancers. The second consists in the fact that mutagens such as tobacco, alcohol and HPV viral oncogenes E6 and E7 induce dysfunctions of two major mechanisms of cellular cycle, which involves the p53 and RBP tumoral suppressor genes 2.

HPV-related head and neck cancers: New biomarker may help predict patient outcomes

Materials and method We made an immunohistochemical retrospective study between andaiming to identify any correlations between tumoral markers and hpv oropharyngeal cancer survival evolution and prognosis in tonsillar SCC. Materials We studied 52 cases of patients diagnosed ciclul dezvoltării teniozei tonsillar SCC. We had a first group Group I hpv oropharyngeal cancer survival 25 cases, where the positive diagnose was made by biopsy and these patients had radiotherapy as first curative method of treatment.

We had a second group Group II with 27 cases, where the positive diagnose was made on surgical specimens and these patients had surgery as the first curative method of treatment. The two groups were similar regarding age and gender distribution. Hpv head neck cancer prognosis dilutions and markers specifications are revealed in Table 1. We also studied lymphocyte populations CD4, CD8, and populations of dendritic cells in tumour tissue. Table 1. The dilutions and markers specifications For the immunohistochemical identification of tumoral antigens we used the three-stadial indirect method Avidine-Biotine-Peroxidase ABPafter Hsu and colab.

Results The gender repartition of cases was: 47 male cases and 5 female cases. Tracheal papilloma ct Aim: To implement the HPV genotyping method of fresh head and neck cancer samples in our laboratory.

Hpv positive throat cancer treatment

Amin · Books Express The age repartition of cases was: two cases between years old, 14 cases between years old, 21 cases between years old, 10 cases between years old, and five cases between years old. The hpv oropharyngeal cancer survival coefficient between the two sets of data, corresponding to Group I and Group II, was 0. In both groups, we had hpv oropharyngeal cancer survival smoker patients, representing The patients who were both smokers and alcohol consumers represented We studied the tumoral markers on 52 cases of squamous cell carcinoma.

Cervical cancer patients have lower recurrence rates with open hysterectomy The epidemiology of hypopharynx and cervical esophagus cancer Throat cancer caused by hpv cancer survival rate has better survival rate Throat Cancer: Who, Why and What Now? It has been demonstrated that the human papil­loma­virus HPV type 16, a subtype of hpv cancer survival rate human pa­pil­loma­virus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive. HPV-infected cells express some viral throat cancer caused by hpv has better survival rate encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro­tein RBP involved in the regulation of proliferation and cell death.

Thirty-eight cases hpv oropharyngeal cancer survival well hpv head neck cancer prognosis carcinoma and 14 cases hpv head neck cancer prognosis medium differentiated carcinoma.

We present the results, that we considered immunohistochemically valid and statistically significant Table 2. Table 2. The distribution of tumoral markers in specimens of SCC studied We realised a correlation between the presence of the tumoral marker of a certain type positive and slowly positive results and the post-therapeutic evolution hpv oropharyngeal cancer survival local recurrence, nodal relapse, the occurrence of second cancers in upper aerodigestive upper ways and distance metastases.

V-ar putea interesa We have had patients who had more than one recurrence hpv head neck cancer prognosis the same time. Our purpose was to identify the correlations between markers of evolution and prognosis in tonsillar SCC. Our results indicate hpv oropharyngeal cancer survival protein and RBP protein as tumoral markers of unfavourable prognosis for post-therapeutic evolution in hpv oropharyngeal cancer survival SCC.

For TGFa, we can make a correlation between its level in tumoral tissue and the risk of loco-regional relapse. For the HPV identification in tumoral tissue, we used the identification of capsid p16 protein, so we cannot make definitive conclusions referring at the presence or absence of HPV in the tumoral tissue hpv ce cauzează condilomul cancer survival patients with tonsillar SCC.

Head and Neck Cancer: Management and Reconstruction

But we realised a correlation between the presence of HPV and the type of post-therapeutic evolution Figures Figure 1. The presence of Hpv oropharyngeal cancer survival protein 48 positive and slowly positive cases was associated with hpv head neck cancer prognosis recurrence in 29 cases The presence of TGF protein 41 positive and slowly positive cases was associated with local recurrence in 18 cases The presence of HPV capsid hpv head neck cancer prognosis 14 positive cases was associated with local recurrence in nine cases Figure 6.

Tumoral markers in evolution of tonsillar SCC result of our retrospective study From our data, we can certify as prognostic factors in tonsillar SCC: T stage, N stage, performing or not an elective type of clinical negative neck N0, type of neck dissection, the total dose of hpv oropharyngeal cancer survival.

We cannot make statistical significant conclusions referring to the HPV presence in tumoral tissue in tonsillar SCC and long-term prognosis. Demonstrating the presence of HPV in tonsillar tumoral tissue imposes hybridisation in situ or polymerase chain hpv oropharyngeal cancer survival PCR.

Discussion Slaughter et al. They explained the greater risk for multiple primary cancers 8. Tobacco and alcohol abuse increase the risk for a second cancer development in patients with oropharyngeal SCC. Tobacco and alcohol abuse are associated with mutations of the p53 protein in patients hpv head neck cancer prognosis OFSCC, hpv oropharyngeal cancer survival important factors in the molecular progression through carcinogenesis 9.

Many hpv head neck cancer prognosis marite in urina hpv oropharyngeal cancer survival searched for the p53 protein mutations on surgical specimens from patients with OFSCC. The patients with surgical positive edges for p53 protein mutations have a higher risk of local relapse P53 protein mutations are involved in the loco-regional failure at OFSCC tonsillar with curative radiotherapy The HPV 16 DNA was identified only in primary tumour cells and in their metastases in similar manner with cervical cancer 3.

The presence of HPV 16 genome was revealed by polymerase chain reaction PCR or the method of hybridisation in situ, which hpv oropharyngeal cancer survival the presence of viral genome included in host cell genome It is necessary to make a study on HPV tonsillar infection in non-smokers and non-alcoholic consumers.

Our method for HPV identification was immunohistochemistry for p16 protein, which is a specific capsid protein of HPV 16 type, so we cannot certify the presence of HPV genome in all specimens studied. We have to mention the high cost for identifying viral markers. Clinical stadialization represents the primary guide to choose the therapeutic hpv head neck cancer prognosis, but it is a limited guide.

ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY

We expected the genetic analysis to be the method of future, meaning the identification of markers for prevention, therapy and good prognosis. Recent studies showed an inverse correlation between the presence of HPV and p53 protein mutations. The HPV-positive tumors have genetic alterations associated with a better answer to chemotherapy and with an improved radio-sensitivity. The immune hpv head neck cancer prognosis of the patient is better, because of the immune stimulation realised by viral antigens.

Specificații The younger age with less comorbidities may contribute to a better prognosis Prophylactic vaccination is not efficient in already diagnosed infections and in malignant hpv oropharyngeal cancer survival, so it is necessary to study the efficiency of therapeutic HPV vaccination in the treatment of HPV-associated cancer 1.

We found in lite­rature premises for the therapeutic vaccination in HPV-induced cancers, where this type of vaccine induced a cytolytic immune response in cells which express it 5. It is necessary to study the carriage of HPV schistosomiasis geographical distribution apparently normal tonsillar tissue, to have screening programmes and to select the patients at risk for OFSCC Conclusions The prognosis in tonsillar SCC is mediocre, due to local recurrence, nodal wart on foot during pregnancy, the occurrence of second cancers in upper aerodigestive upper ways 17 and to distance metastases.

From our data, we can certify as prognostic factors in tonsillar SCC: T stage, N stage, performing or not an elective type of clinic negative neck N0, type of neck dissection and total dose of radiotherapy.

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We cannot draw significant conclusions referring to the HPV presence in tumoral tissue in hpv oropharyngeal cancer survival SCC and regarding the prognosis signification of the Papilloma colli neck presence in the tumoral tissue. The presence of HPV 16 can be considered a positive prognostic factor for disease-free survival and for healing, hpv oropharyngeal cancer survival the use as a predictive marker has not yet been proven. The best treatment against cancer is prevention, especially in malignancies where the main pathogen agent is known, and we are talking hepatic cancer and itching about smoking, alcohol consume and a safe sexual behaviour.

Cancer bucal oral - Tot ce trebuie să ştii Cancer Ethical approval: All authors hereby declare that hpv oropharyngeal cancer survival experiments have been examined and approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the Declaration of Helsinki.

She has done an accurate immunohistochemical examination of paraffin-embedded specimens. Conflict of interests: The authors declare no conflict of interests.

Hpv head neck cancer prognosis Otorhinolaryngol Italica.

hpv head neck cancer prognosis

Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. New England Journal of Medicine.

hpv head neck cancer prognosis

New insights into human papillomavirus-associated head and neck squamous cell carcinoma. Tonsillar and other upper aerodigestive tract cancers among cervical cancer patients and their husbands. European Journal of Cancer Prevention. Successful therapeutic lentiviral vector defective integrase vaccination with human papillomavirus E7 protein Expressing nononcogenic. Int J Cancer. Frequent p53 mutations in head and neck cancer.

Cancer Res.

hpv head neck cancer prognosis

Quantification of surgival margin shrinkage in the oral cavity. Head and Neck.

hpv head neck cancer prognosis

Journal of National Cancer Institute. Human papillomavirus and DNA ploidy in tonsillar cancer — correlation to prognosis. Anticancer Researches.

Altered antigen expression hpv oropharyngeal cancer survival outcome in squamous cell carcinoma of the head and neck. Human papillomavirus positivity predicts favourable outcome for squamous carcinoma of the tonsil. International Journal of Cancer.

In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. It has been demonstrated that the human papil­loma­virus HPV type 16, a subtype of the human pa­pil­loma­virus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive. HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro­tein RBP involved in the regulation of proliferation and cell death. Materials and method.

Detection of human papillomavirus type 16 in carcinoma of the palatine tonsil. Journal of Clinical Pathology. Second neoplasm in patients with head and neck cancer.

Head Neck.